Antiretroviral drugs interaction with antihypertensive drugs on HWN RESEARCH

Antihypertensive drugs interact with several antiretroviral drugs, nonnucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs) in particular. Pharmacokinetic interactions are less expected with diuretics, β-blockers excreted by the kidney, angiotensin-converting enzyme (ACE) inhibitors, and angiotensin II receptor blockers (ARBs) other than losartan and irbesartan. Calcium channel blockers (CCBs) are metabolized by CYP3A4, with the potential for interaction with NNRTIs and PIs. Because CCBs do not adversely affect glucose or lipid metabolism or renal function, they may be preferred in patients with such complications. ACE inhibitors and ARBs may exert favorable effects on glucose homeostasis. In addition, they may significantly reduce protein excretion and further slow the progression of renal disease.

Conclusion: The choice of antihypertensive drugs in HIV-infected patients is complex and must take into account the metabolic pathways of antiretroviral drugs and antihypertensive drugs with the potential of pharmacokinetic interactions, as well as the effect of antihypertensive drugs on some biological parameters.

Source: PubMed, DWN Africa.